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Magnetic resonance spectroscopy (MRS) is an important clinical imaging methodfor diagnosis of diseases. MRS spectrum is used to observe the signal intensityof metabolites or further infer their concentrations. Although the magneticresonance vendors commonly provide basic functions of spectra plots andmetabolite quantification, the widespread clinical research of MRS is stilllimited due to the lack of easy-to-use processing software or platform. Toaddress this issue, we have developed CloudBrain-MRS, a cloud-based onlineplatform that provides powerful hardware and advanced algorithms. The platformcan be accessed simply through a web browser, without the need of any programinstallation on the user side. CloudBrain-MRS also integrates the classicLCModel and advanced artificial intelligence algorithms and supports batchpreprocessing, quantification, and analysis of MRS data from different vendors.Additionally, the platform offers useful functions: 1) Automaticallystatistical analysis to find biomarkers for diseases; 2) Consistencyverification between the classic and artificial intelligence quantificationalgorithms; 3) Colorful three-dimensional visualization for easy observation ofindividual metabolite spectrum. Last, both healthy and mild cognitiveimpairment patient data are used to demonstrate the functions of the platform.To the best of our knowledge, this is the first cloud computing platform for invivo MRS with artificial intelligence processing. We have shared our cloudplatform at MRSHub, providing free access and service for two years. Pleasevisit https://mrshub.org/software_all/#CloudBrain-MRS orhttps://csrc.xmu.edu.cn/CloudBrain.html.

CloudBrain-MRS: An Intelligent Cloud Computing Platform for in vivo Magnetic Resonance Spectroscopy Preprocessing, Quantification, and Analysis