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Coronavirus disease 2019 in solid organ transplant (SOT) patients isassociated with more severe outcomes than non-immunosuppressed hosts. However,exactly which risk factors cause Long COVID in acute COVID cases remainsunknown. More importantly, the impact of Long COVID on patient survival remainsunderstudied, especially when examined alongside the effect of SOT. Allpatients have been identified with acute COVID in the National COVIDCollaborative Cohort registry. We compared patient demographics in Long COVIDvs. those without Long COVID based on descriptive statistics. Multivariablelogistics regressions were used to determine the factors related to thelikelihood of developing Long COVID from a case of acute COVID. Multi-variablesCox regression was used to determine the time-to-event outcome of patientsurvival with Long COVID. This study reviewed data from a cohort of 6,416,500acute COVID patients. Of that group, 31,744 patients developed Long COVID fromICD diagnosis. The mean (q1, q3) age was 39 (22, 57) years old, and 55% ofpatients were female. From this cohort, a total of 31,744 (1%) developed LongCOVID and 43,565 (1%) had SOT, with a total of 698 SOT patients identified withLong COVID. Mean age of those with Long COVID was 52 (39, 64) years old and 64%of patients were female. Most of the SOT patients were kidney transplantrecipients. From the Cox regression analysis of patient survival, there weremany significant factors related to patient survival, with elderly SOT patientshaving a much higher hazard ratio of 27.8 (26.3, 29.4). This study hasidentified the important risk factors that are more likely to cause Long COVIDin an acute COVID cohort. We investigated hazard ratios of patient survivalbased on multivariable Cox models, which found that Long COVID had a moredirect impact on survival in elderly patients and those with SOT.

What Risk Factors to Cause Long COVID and Its Impact on Patient Survival  Outcomes when Combined with the Effect from Organ Transplantation in the  Acute COVID