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Spatiotemporal coordination of chromatin and subnuclear compartments iscrucial for cells. Numerous enzymes act inside nucleus\textemdash some of thosetransiently link and pass two chromatin segments. Here we study how such anactive perturbation affects fluctuating dynamics of an inclusion in thechromatic medium. Using numerical simulations and a versatile effective model,we categorize inclusion dynamics into three distinct modes. Thetransient-link-and-pass activity speeds up inclusion dynamics by affecting aslow mode related to chromatin remodeling, viz., size and shape of thechromatin meshes.

Chromatin remodeling due to transient-link-and-pass activity enhances subnuclear dynamics