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In this letter, we present anti-cancer drug delivery strategies usingknowledges obtained from our recent studies. We have conducted inverse analysesof "density distributions of colloidal particles near a focused surface" and"pair potentials between the surface and the colloidal particle" using datameasured by optical tweezers (OT) and atomic force microscopy (AFM).Non-additive Asakura-Oosawa (NAO) theory and a lattice theory in statisticalmechanics of simple polymers have been also our research topics. Summarizingthe knowledges, we propose two strategies to increase the delivery rate ofcapsule shaped anti-cancer drugs to cancer cells. We consider that enhancedrepulsion between the normal cell and the drug accelerates the attractionbetween the cancer cell and the drug, which can be named enhanced repulsion andaccelerated adsorption (ERAA) effect. To realize the ERAA effect, we propose asupporting method for measuring the interactions using OT and AFM. In thesecond strategy, dose of water-soluble polymers is considered to realizeadsorptions of the drugs and cancer cell derived exosomes onto the cancercells, which we call non-specific and selective adsorption (NSSA) effect. Inthe main text, we explain the NSSA effect using the NAO theory. Moreover, weexplain that structural stabilities of normal dispersed proteins around thecancer cells are not largely destroyed by the dosed polymers from the viewpointof the lattice theory.

Strategies for deliveries of anti-cancer drugs from perspectives of a measurement theory and an adsorption theory