English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

The interaction between metallic and biological nanoparticles (NPs) is widelyused in various biotechnology and biomedical applications. However, detailedcharacterization of this type of interaction is challenging due to a lack ofhigh-throughput techniques that can quantify both size and composition ofsuspended NP complexes. Here, we introduce a technique called ``twilightnanoparticle tracking analysis'' (tNTA) and demonstrate that it provides aquantitative relationship between the measured optical signal and thecomposition of suspended dielectric-metal NP complexes. We assess theperformance of tNTA by analyzing the selective binding of tannic acid-modifiedgold nanoparticles (TaAuNPs) to herpes simplex viruses (HSV). Our results showthat TaAuNPs bind specifically to HSV without causing substantial changes inthe size or refractive index of the virus, suggesting that the binding does notcause virus disruption. Instead, the anti-viral properties of TaAuNPs appear tostem from direct particle binding to the virus.

Label-free optical quantification of material composition of suspended virus-gold nanoparticle complexes