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RNA folding prediction remains challenging, but can be also studied using atopological mathematical approach. In the present paper, the mathematicalmethod to compute the topological classification of RNA structures and based onmatrix field theory is shortly reviewed, as well as a computational software,McGenus, used for topological and folding predictions. Additionally, two typesof analysis are performed: the prediction results from McGenus are comparedwith topological information extracted from experimentally-determined RNAstructures, and the topology of RNA structures is investigated for biologicalsignificance, in both evolutionary and functional terms. Lastly, we advocatefor more research efforts to be performed at intersection ofphysics-mathematics and biology, and in particular about the possiblecontributions that topology can provide to the study of RNA folding andstructure.

Genus Comparisons in the Topological Analysis of RNA Structures