English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

The idea of a systematic digital representation of the entire known humanpathophysiology, which we could call the Virtual Human Twin, has been aroundfor decades. To date, most research groups focused instead on developing highlyspecialised, highly focused patient-specific models able to predict specificquantities of clinical relevance. While it has facilitated harvesting thelow-hanging fruits, this narrow focus is, in the long run, leaving somesignificant challenges that slow the adoption of digital twins in healthcare.This position paper lays the conceptual foundations for developing the VirtualHuman Twin (VHT). The VHT is intended as a distributed and collaborativeinfrastructure, a collection of technologies and resources (data, models) thatenable it, and a collection of Standard Operating Procedures (SOP) thatregulate its use. The VHT infrastructure aims to facilitate academicresearchers, public organisations, and the biomedical industry in developingand validating new digital twins in healthcare solutions with the possibilityof integrating multiple resources if required by the specific context of use.Healthcare professionals and patients can also use the VHT infrastructure forclinical decision support or personalised health forecasting. As the EuropeanCommission launched the EDITH coordination and support action to develop aroadmap for the development of the Virtual Human Twin, this position paper isintended as a starting point for the consensus process and a call to arms forall stakeholders.

From the digital twins in healthcare to the Virtual Human Twin: a moon-shot project for digital health research