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Intravoxel Incoherent Motion (IVIM) is a non-contrast magnetic resonanceimaging diffusion-based scan that uses a multitude of b-values to measurevarious speeds of molecular perfusion and diffusion, sidestepping inaccuracy ofarterial input functions or bolus kinetics in quantitative imaging. We test anew method of IVIM quantification and compare our values to reference standardneutron capture microspheres across normocapnia, CO2 induced hypercapnia, andmiddle cerebral artery occlusion in a controlled animal model. Perfusionquantification in ml/100g/min compared to microsphere perfusion uses the 3Dgaussian probability distribution and defined water transport time as when 50%of the molecules remain in the tissue of interest. Perfusion, water transporttime, and infarct volume was compared to reference standards. Simulations werestudied to suppress non-specific cerebrospinal fluid (CSF). Linear regressionanalysis of quantitative perfusion returned correlation (slope = .55, intercept= 52.5, $R^2$= .64). Linear regression for water transport time asymmetry ininfarcted tissue was excellent (slope = .59, intercept = .3, $R^2$ = .93).Strong linear agreement also was found for infarct volume (slope = 1.01, $R^2$=.79). Simulation of CSF suppression via inversion recovery returned bloodsignal reduced by 82% from combined T1 and T2 effects. Intra-physiologic statecomparison of perfusion shows potential partial volume effects which requirefurther study especially in disease states. The accuracy and sensitivity ofIVIM provides evidence that observed signal changes reflect cytotoxic edema andtissue perfusion. Partial volume contamination of CSF may be better removedduring post-processing rather than with inversion recovery to avoid artificialloss of blood signal.

Quantitative perfusion and water transport time model from multi b-value  diffusion magnetic resonance imaging validated against neutron capture  microspheres