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We theoretically propose that the monolayer V$_2 MX_4$ ($M=$ W, Mo; $X=$ S,Se) is a new family of quantum anomalous Hall insulators with sizable bulk gapand Chern number $\mathcal{C}=-1$. The interplay between topology and magnetismin this class of compounds are from $d$-orbitals of both V and $M$. Weconstruct the tight-binding model from orbital projected band structure andsymmetry analysis to uncover the origin of topology. Remarkably, the topologyis not only from the spin polarized quadratic band touching of degenerate$d_{xz}$ and $d_{yz}$ orbitals of V guaranteed by $C_{4z}$ symmetry, but alsothe band inversion between $d_{xz},d_{yz}$ orbitals of V and $d_{z^2}$ of $M$at Fermi level, which is further gapped by spin-orbit coupling. This results inthe Chern band lying far below Fermi energy. Furthermore, the thicknessdependence of the Chern number for few multilayers shows interestingoscillating behavior. The general physics from the $d$-orbitals here applies toa large class of ternary transition metal chalcogenide such as Ti$_2$W$X_4$with the space group $P$-$42m$.

Monolayer V2MX4: A new family of quantum anomalous Hall insulators