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We have developed a mathematical model that captures stress-inducedmutagenesis, a fundamental aspect of pathogenic and neoplastic evolutionarydynamics, on the fitness landscape with multiple relevant genetic traits as ahigh-dimensional Euclidean space. In this framework, stress-induced mutagenesismanifests as a heterogeneous diffusion process. We show how increasingmutations, and thus reducing exploitation, in a static ecology with fixedcarrying capacity and maximum growth rates, can paradoxically boost populationsize. Remarkably, this unexpected biophysical phenomenon applies universally toany number of traits.

Stress-Induced Mutagenesis Can Further Boost Population Success in Static Ecology