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A cooperative drug delivery system is proposed, where quorum sensing (QS), adensity-dependent bacterial behavior coordination mechanism, is employed bysynthetic bacterium-based nanomachines (B-NMs) for controllable drug delivery.In our proposed system, drug delivery is only triggered when there are enoughQS molecules, which in turn only happens when there are enough B-NMs. Thismakes the proposed system can be used to achieve a high release rate of drugmolecules from a high number of B-NMs when the population density of B-NMs maynot be known. Analytical expressions for i) the expected activation probabilityof the B-NM due to randomly-distributed B-NMs and ii) the expected aggregateabsorption rate of drug molecules due to randomly-distributed QS activatedB-NMs are derived. Analytical results are verified by particle-basedsimulations. The derived results can help to predict and control the impact ofenvironmental factors (e.g. diffusion coefficient and degradation rate) on theabsorption rate of drug molecules since rigorous diffusion-based molecularchannels are considered. Our results show that the activation probability atthe B-NM increases as this B-NM is located closer to the center of the B-NMpopulation and the aggregate absorption rate of the drug molecules non-linearlyincreases as the population density increases.

Molecular Communication for Quorum Sensing Inspired Cooperative Drug Delivery