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. Treatment planning systems (TPS) are an essential component forsimulating and optimizing a radiation therapy treatment before administering itto the patient. It ensures that the tumor is well covered and the dose to thehealthy tissues is minimized. However, the TPS provided by commercial companiesoften come with a large panel of tools, each implemented in the form of ablack-box making it difficult for researchers to use them for implementing andtesting new ideas. To address this issue, we have developed an open-source TPS.Approach. We have developed an open-source software platform, OpenTPS(opentps.org), to generate treatment plans for external beam radiation therapy,and in particular for proton therapy. It is designed to be a flexible anduser-friendly platform (coded with the freely usable Python language) that canbe used by medical physicists, radiation oncologists, and other members of theradiation therapy community to create customized treatment plans foreducational and research purposes. Result. OpenTPS includes a range of toolsand features that can be used to analyze patient anatomy, simulate the deliveryof the radiation beam, and optimize the treatment plan to achieve the desireddose distribution. It can be used to create treatment plans for a variety ofcancer types and was designed to be extended to other treatment modalities.Significance. A new open-source treatment planning system has been built forresearch in proton therapy. Its flexibility allows an easy integration of newtechniques and customization of treatment plans. It is freely available for useand is regularly updated and supported by a community of users and developerswho contribute to the ongoing development and improvement of the software.

OpenTPS -- Open-source treatment planning system for research in proton therapy