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Escherichia coli is one of many bacterial inhabitants found in humanintestines and any adaptation as a result of mutations may affect its host. Acommonly used technique employed to study these mutations is RestrictionFragment Length Polymorphism (RFLP) and is proceeded with a suitable distancecoefficient to quantify genetic differences between 2 samples. Dice isconsidered a suitable distance coefficient in RFLP analyses, while others wereleft unstudied in its suitability for use. Hence, this study aims to identifysubstitutes for Dice. Experimental data was obtained by subculturing E. colifor 72 passages in 8 different adaptation media and RFLP profiles analyzedusing 20 distance coefficients. Our results suggest that Dennis, Fossum,Matching and Russel and Rao to work as well or better than Dice. Dennis,Matching and Fossum coefficients had highest discriminatory abilities but arelimited by the lack of upper or lower boundaries. Russel and Rao coefficient ishighly correlated with Dice coefficient (r2 = 0.998), with both higher andlower boundaries, suggesting that Russel and Rao coefficient can be used tosubstitute Dice coefficient in studying genetic distances in E. coli.

Russel and Rao Coefficient is a Suitable Substitute for Dice Coefficient in Studying Restriction Mapped Genetic Distances of Escherichia coli