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Purpose: Commercial UHDR platforms deliver Ultra-High Dose Rate (UHDR) dosesat discrete combinations of pulse parameters including pulse width (PW), pulserepetition frequency (PRF) and number of pulses (N), which dictate uniquecombinations of dose and dose rates. Currently, obtaining pulse parameters forthe desired dose and dose rate is a cumbersome manual process involvingcreating, updating, and looking up values in large spreadsheets for everytreatment configuration. The purpose of this work is to present a pulseparameter optimizer application to match intended dose and dose rate preciselyand efficiently.  Methods: Dose and dose rate calculation have been described for a commercialelectron FLASH platform. A constrained optimization for the dose and dose ratecost function was modelled as a mixed integer problem in MATLAB (The MathWorksInc., Version9.13.0 R2022b, Natick, Massachusetts). The beam and machine datarequired for the application were acquired using GafChromic film andAlternating Current Current Transformers (ACCTs). Variables for optimizationincluded dose per pulse (DPP) for every collimator at a specific treatmentconfiguration, PW and PRF measured using ACCT, and airgap factors.  Results: Using PW, PRF, N and airgap factors as the parameters, theapplication was created to optimize for dose and dose rate. Largely automatingdose and dose rate calculation reduces safety concerns associated with manuallook up and calculation of these parameters, especially when many subjects atdifferent doses and dose rates are to be safely managed.  Conclusion: A pulse parameter optimization application was built in MATLABfor a commercial electron UHDR platform to increase efficiency in the dose,dose rate, and pulse parameter prescription process.

Pulse Parameter Optimization Method for Ultra High Dose Rate Electron Treatment