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Objective: Identifying abnormalities in interictal intracranial EEG, bycomparing patient data to a normative map, has shown promise for thelocalisation of epileptogenic tissue and prediction of outcome. The approachtypically uses short interictal segments of around one minute. However, thetemporal stability of findings has not been established.  Methods: Here, we generated a normative map of iEEG in non-pathological braintissue from 249 patients. We computed regional band power abnormalities in aseparate cohort of 39 patients for the duration of their monitoring period(0.92-8.62 days of iEEG data, mean 4.58 days per patient, over 4,800 hoursrecording). To assess the localising value of band power abnormality, wecomputed DRS - a measure of how different the surgically resected and sparedtissue were in terms of band power abnormalities - over time.  Results: In each patient, band power abnormality was relatively consistentover time. The median DRS of the entire recording period separated seizure free(ILAE = 1) and not seizure free (ILAE > 1) patients well (AUC = 0.69). Thiseffect was similar interictally (AUC = 0.69) and peri-ictally (AUC = 0.71).  Significance: Our results suggest that band power abnormality DRS, as apredictor of outcomes from epilepsy surgery, is a relatively robust metric overtime. These findings add further support for abnormality mapping ofneurophysiology data during presurgical evaluation.

Temporal stability of intracranial EEG abnormality maps for localising epileptogenic tissue