English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Objective: To discover biomarkers and uncover the mechanism of Cold/Hot ZHENG(syndrome in traditional Chinese medicine) chronic gastritis (CG) and Cold/Hotherbs in traditional Chinese medicine (TCM) formulae on systematic biology.Background: CG is a common inflammatory disease and the diagnosis of CG in TCMcan be classified into Cold ZHENG (Asthenic Cold) and Hot ZHENG (Excess Hot).However, the molecular features of Cold/Hot ZHENG in CG and the mechanism ofCold/Hot herbs in formulae for CG remained unclear. Methods: Based on data of35 patients of Cold/Hot ZHENG CG and 3 scRNA-seq CG samples, we conductanalysis with transcriptomics datasets and algorithms, to discover biomarkersfor Cold/Hot ZHENG CG. And we collected 25 formulae (with traditional effectsrelated to Cold/Hot ZHENG) for CG and corresponding 89 Cold/Hot herbs(including Warm/Cool herbs) to discover features and construct target networksof Cold/Hot herbs on the basis of network target and enrichment analysis.Results: Biomarkers of Cold/Hot ZHENG CG represented by CCL2 and LEP suggestedthat Hot ZHENG CG might be characterized by over-inflammation and exuberantmetabolism, and Cold ZHENG CG showed a trend of suppression in immuneregulation and energy metabolism. And biomarkers of Cold/Hot ZHENG showed alsosignificant changes in the progression of gastric cancer. And biomarkers andpathways of Hot herbs intend to regulate immune responses and energymetabolism, while those of Cold herbs were likely to participate inanti-inflammation effect. Conclusion: In this study, we found that thebiomarkers and mechanism of Cold/Hot ZHENG CG and those of Cold/Hot herbs wereclosely related to the regulation of immune and metabolisms. These findings mayreflect the mechanism, build bridges between multiple views of Cold/Hot ZHENGand Cold/Hot herbs, and provide a research paradigm for further achievingprecision TCM.

A network-based biomarkers discovery of Cold/Hot ZHENG chronic gastritis and Cold/Hot herbs of formulae