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Super-paramagnetic nanoparticles (NPs) have been widely explored as magneticresonance imaging (MRI) contrast agents because of a combination of favorablemagnetic properties, biocompability and ease of fabrication. MRI usingtraditional T1- or T2-weighted single mode contrast-enhanced techniques mayyield inaccurate imaging results. In the present work, a T1/T2 dual modecontrast agent based on the super-paramagnetic zinc-manganese ferrite(Zn$_{0.3}$Mn$_x$Fe$_{2.7-x}$O$_4$, x= 0, 0.25, 0.75 and 1) NPs with small coresize and a hydrophilic PEG surface coating is reported. The TEM, TGA and FTIRresults confirmed the formation of a uniform coating on the NPs surface. TheMRI analysis revealed that the Zn$_{0.3}$Mn$_{0.5}$Fe$_{2.2}$O$_4$ NPs had themaximum image contrast compared to other zinc-manganese ferrite samples. Cellviability evaluations revealed that the coated and uncoated particles did notinhibit cell growth pattern. The present PEG-coatedZn$_{0.3}$Mn$_{0.5}$Fe$_{2.2}$O$_4$ NPs can be utilized as a suitableT1/T2-weighted MRI contrast agent for better diagnostic of abnormalities in theorgans or tissues.

Synthesis and characterization of PEG-coated Zn$_{0.3}$Mn$_x$Fe$_{2.7-x}$O$_4$ nanoparticles as the dual T1/T2-weighted MRI contrast agent