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The adaptation rate in theoretical models of biological evolution increaseswith the mutation rate but only to a point when mutations into lethal statescause extinction. One would expect that removing such states should bebeneficial for evolution. We show here that, counter-intuitively, lethalmutations speed up adaptation on rugged fitness landscapes with many fitnessmaxima and minima, if strong competition for resources exist. We consider amodified stochastic version of the quasispecies model with two types ofgenotypes, viable and lethal, and show that increasing the rate of lethalmutations decreases the time to evolve the best-fit genotype. This can beexplained by an increased rate of crossing fitness valleys, facilitated byreduced selection against less-fit variants.

Evolutionary adaptation is facilitated by the presence of lethal genotypes