English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

In many biopolymer solutions, attractive interactions that stabilizefinite-sized clusters at low concentrations also promote phase separation athigh concentrations. Here we study a model biopolymer system that exhibits theopposite behavior: Self-assembly of DNA oligonucleotides into finite-sized,stoichiometric clusters, known as "DNA nanostars", tends to inhibit phaseseparation of the oligonucleotides at high temperatures. We usemicrofluidics-based experiments to map the phase behavior of DNA nanostars athigh concentrations of divalent cations, revealing a novel phase transition inwhich the oligonucleotides condense upon increasing temperature. We then showthat a theoretical model of competition between self-assembly and phaseseparation quantitatively predicts changes in experimental phase diagramsarising from DNA sequence perturbations. Our results point to a generalmechanism by which self-assembly shapes phase boundaries in complex biopolymersolutions.

Competition between self-assembly and phase separation governs high-temperature condensation of a DNA liquid