English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Axes of polarity (and primary morphogenetic gradients) are established in theoocyte - early embryo through active transport and localization of maternalfactors. It is the oocyte - syncytial embryo of Drosophila (D. melanogaster)that is a model object for studying the molecular machinery of such transportsystems. The attention of researchers is focused on the processes of formation,maintenance, and functioning of active transport systems of maternal mRNAs andproteins that are key for early Drosophila embryogenesis. Here we develop anapproach for agent-based 3D modeling of the key components of transport bymolecular motors (by elements of the cytoskeleton) of the Drosophilaoocyte-syncytial embryo. The models were developed using Skeledyne softwaredeveloped by Odell and Foe [Odell and Foe, 2008]. We start with the results ofmodeling transport along oriented microtubule (MT) bundles in the oocyte. Thisis a model of transport systems in the Drosophila oocyte, where three maternalmRNAs (bicoid (bcd), oskar, and gurken) that are key to embryonic polarity aretransported along their oriented MT bundles. Then we consider models oforiented MT networks in the volume of a cell (oocyte) generated by a singlemicrotubule organization center (or a pair of the centers). This modelreproduces the formation of bcd mRNA intrusions deep into the cytoplasm in thehead half of the early syncytial embryo. Finally, we consider models for theactive transport of bcd mRNA in a syncytial embryo along a randomized networkof many short MT strands. In conclusion, we consider the prospects for theimplementation of cytoplasmic fountain flows in the active transport model.

mRNA active transport in oocyte-early embryo: 3D agent-based modeling