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Agreement between measurement methods is commonly investigated by a so-calledBland-Altman plot showing if the difference is independent of the size of themeasurement. However, such analysis assumes that both methods have the sameprecision. If not, the plot may show a false trend caused by the difference inprecision and not by an actual dependence on the size of the measurement. Wesuggest a modification of the Bland-Altman plot such that the differences areplotted against an inverse-variance weighted average of the measurements ratherthan their mean. This study shows that such modification removes the dependenceon difference in precision.

Investigating the agreement between methods of different precision