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Dark matter-baryon interactions can cool the baryonic fluid, which has beenshown to modify the cosmological 21-cm global signal. We show that in atwo-component dark sector with an interacting millicharged component, darkmatter-baryon scattering can produce a 21-cm power spectrum signal withacoustic oscillations. The signal can be up to three orders of magnitude largerthan expected in $\Lambda$CDM cosmology, given realistic astrophysical models.This model provides a new-physics target for near-future experiments such asHERA or NenuFAR, which can potentially discover or strongly constrain the darkmatter explanation of the putative EDGES anomaly.

Anticipating a New-Physics Signal in Upcoming 21-cm Power Spectrum Observations