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X-ray micro tomography is a non-destructive, three-dimensional inspectiontechnique applied across a vast range of fields and disciplines, ranging fromresearch to industrial, encompassing engineering, biology and medical research.Phase-contrast imaging extends the domain of application of X-ray microtomography to classes of samples that exhibit weak attenuation, thus appearwith poor contrast in standard X-ray imaging. Notable examples arelow-atomic-number materials, like carbon-fibre composites, soft matter andbiological soft tissues. We report on a compact and cost effective system forX-ray phase-contrast micro tomography. The system features high sensitivity tophase gradients and high resolution, requires a low-power sealed X-ray tube, asingle optical element, and fits in a small footprint. It is compatible withstandard X-ray detector technologies: single-photon-counting offers highersensitivity whereas flat-panels are preferred for a larger field of view. Thesystem is benchmarked against known-material phantoms and its potential forsoft-tissue three-dimensional imaging is demonstrated on small-animal organs: apiglet oesophagus and a rat heart.

X-ray phase-contrast micro tomography of soft tissues using a compact laboratory system with two-directional sensitivity