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Burn wounds can severely trouble the health system and life quality ofpatients. The present study aimed to analyze the synergistic healing propertiesof curcumin, honey, and potassium alum substances merged in a newly-devisedburn ointment on second-degree burn wounds in rats. The MIC and MBC tests on200 clinical isolates of Pseudomonas aeruginous are compared to imipenem invitro. Their killing time and cytotoxicity are also studied using a standardisolate of P. aeruginous, fibroblast stem cells (FSC) and mouse embryonicfibroblasts (MEF). Furthermore, histopathological and histomorphologicalassessments are conducted on 150 male Wistar rats whitin four experimentalgroups to evaluate the efficiency of the prepared burn ointment. We found asignificant wound healing in both macroscopical observations and microscopicalevaluations. Both curcumin and honey show strong antimicrobial effects with nocytotoxicity. Also, the histopathological results present a considerable andcomparable wound re-epithelization in the a group of rats treated with bothhoney and curcumin after 7 days. The burn ointment containing curcumin, honey,and potassium alum show considerable efficacy in accelerating the healing ofexperimentally-induced burn wounds in animals. Th novel onement product ispropose as a powerful alternative for the topical treatment of burn injuries.

Evaluation of the Antibacterial and Wound Healing Properties of a Burn Ointment Containing Curcumin, Honey, and Potassium Aluminium