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Background: RNA guanine-7 methyltransferase (RNMT) is one of the mainregulators of N7-methylguanosine, and the deregulation of RNMT correlated withtumor development and immune metabolism. However, the specific function of RNMTin pan-cancer remains unclear.  Methods: RNMT expression in different cancers was analyzed using multipledatabases, including Cancer Cell Line Encyclopedia (CCLE), Genotype-TissueExpression Project (GTEx), and The Cancer Genome Atlas (TCGA). Cox regressionanalysis and Kaplan-Meier analysis were used to estimate the correlation ofRNMT expression to prognosis. The data was also used to research therelationship between RNMT expression and common immunoregulators, tumormutation burden (TMB), microsatellite instability (MSI), mismatch repair (MMR),and DNA methyltransferase (DNMT). Additionally, the cBioPortal website was usedto evaluate the characteristics of RNMT alteration. The TISDB database was usedto obtain the expression of different subtypes. The Tumor Immune EstimationResource (TIMER) database was used to analyze the association between RNMT andtumor immune infiltration. Gene set enrichment analysis (GSEA) was used toidentify the relevant pathways.  Results: RNMT was ubiquitously highly expressed across cancers and survivalanalysis revealed that its expression was highly associated with the clinicalprognosis of various cancer types. Remarkably, RNMT participates in immuneregulation and plays a crucial part in the tumor microenvironment. A positiveassociation was found between RNMT expression and six immune cell typesexpression in colon adenocarcinoma, kidney renal clear cell carcinoma, andliver hepatocellular carcinoma. Moreover, RNMT expression was highly associatedwith immunoregulators in most cancer types, and correlated to TMB, MSI, MMR,and DNMT. Finally, GSEA indicated that RNMT may correlate with tumor immunity.

Integrative Pan-Cancer Analysis of RNMT: a Potential Prognostic and Immunological Biomarker