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A synapse acts on neural transmission through a chemical process calledsynapses fusion between pre-synaptic and post-synaptic terminals. Presynapticterminals release neurotransmitters either in response to action potential orspontaneously independent of presynaptic activity. However, it is still unclearthe mechanism of evoked and spontaneous neuro-transmission that activate onpostsynaptic terminals. To address this question, we examined the possibilitythat spontaneous and evoked neurotransmissions using mathematical simulations.We aimed to address the biophysical constraints that may determine independentactivation on N-methyl-D-asparate (NMDA) receptor mediated currents in responseto evoked and spontaneous glutamate molecules releases. In order to identifythe spatial relation between spontaneous and evoked glutamate release, weconsidered quantitative factors, such as size of synapses, inhomogeneity ofdiffusion mobility, geometry of synaptic cleft, and release rate ofneurotransmitter. Simulation results showed that as a synaptic size is smallerand if the cleft space is more cohesive in the peripheral area than the centrearea, then there is high possibility of having crosstalk of two signalsreleased from center and edge. When a synaptic size is larger, the cleft spaceis more affinity in the central area than the external area, and if thegeometry of fusion has a narrower space, then those produce more chances ofindependence of two modes of currents released from center and edge. Thecomputed results match well with existing experimental findings and serve as aroad map for further exploration to identify independence of evoked andspontaneous releases.

Quantifying constraints determining independent activation on NMDA  receptors mediated currents from evoked and spontaneous synaptic transmission  at an individual synapse