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This report was prepared on behalf of three Energy Frontier Topical Groups ofthe Snowmass 2021 Community Planning Exercise. It summarizes the status andimplications of studies of strong interactions in high-energy experiments andQCD theory. We emphasize the rich landscape and broad impact of these studiesin the decade ahead. Hadronic interactions play a central role in thehigh-luminosity Large Hadron Collider (LHC) physics program, and strongsynergies exist between the (HL-)LHC and planned or proposed experiments at theU.S. Electron-Ion Collider, CERN forward physics experiments, high-intensityfacilities, and future TeV-range lepton and hadron colliders. Prospects forprecision determinations of the strong coupling and a variety ofnonperturbative distribution and fragmentation functions are examined. We alsoreview the potential of envisioned tests of new dynamical regimes of QCD inhigh-energy and high-density scattering processes with nucleon, ion, and photoninitial states. The important role of the high-energy heavy-ion program instudies of nuclear structure and the nuclear medium, and its connections withQCD involving nucleons are summarized. We address ongoing and futuretheoretical advancements in multi-loop QCD computations, lattice QCD, jetsubstructure, and event generators. Cross-cutting connections betweenexperimental measurements, theoretical predictions, large-scale data analysis,and high-performance computing are emphasized.

Precision QCD, Hadronic Structure & Forward QCD, Heavy Ions: Report of Energy Frontier Topical Groups 5, 6, 7 submitted to Snowmass 2021