English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

In this article, I put forward the idea that the neoplastic process (NP) hasdeep evolutionary roots and make specific predictions about the connectionbetween cancer and the formation of the first embryo, which allowed for theevolutionary radiation of metazoans. My main hypothesis is that the NP is atthe heart of cellular mechanisms responsible for animal morphogenesis and,given its embryological basis, also at the center of animal evolution. It isthus understood that NP-associated mechanisms are deeply rooted in evolutionaryhistory and tied to the formation of the first animal embryo. In myconsideration of these arguments, I expound on how cancer biology is perfectlyintertwined with evolutionary biology. I describe essential cellular componentsof unicellular holozoans that served as a basis for the formation of theneoplastic functional module (NFM) and its subsequent exaptation, which broughtforth two great biophysical revolutions within the first embryo. Finally, Iexamine the role of Physics in the modeling of the NFM and its contribution tomorphogenesis to reveal the totipotency of the zygote.

The Neoplasia as embryological phenomenon and its implication in the  animal evolution and the origin of cancer. II. The neoplastic process as an  evolutionary engine