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Two isoforms of beta amyloid peptides, Ab40 and Ab42, differ from each otheronly in the last two amino acids, IA, at the end of Ab42. They, however, differsignificantly in their ability in inducing Alzheimer's disease (AD). The ratecurves of fibril growth of Ab40 and Ab42 and the effects of molecular crowdinghave been measured in in vitro experiments. These experimental curves, on theother hand, have been fitted in terms of rate constants for elementary reactionsteps using rate equation approaches. Several sets of such rate parameters havebeen reported in the literature. Employing a recently developed stochastickinetic method, implemented in a browser-based simulator, popsim, we study toreveal the differences in the kinetic behaviors implied by these sets of rateparameters. In particular, the stochastic method is used to distinguish thekinetic behaviors between Ab40 and Ab42 isoforms. As a result, we make generalcomments on the usefulness of these sets of rate parameters.

Stochastic Kinetic Study of Protein Aggregation and Molecular Crowding Effects of Ab40 and Ab42