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Since the first case of COVID-19 disease in Wuhan in December 2019, there isa worldwide struggle to reduce the transmission of acute respiratory syndromecoronavirus SARS-CoV-2. Many countries worldwide decided to impose locallockdowns in order to reduce person-to-person interactions, masks becameobligatory especially in closed spaces, and there was a general requirement forsocial distance. However, the most efficient method to reduce continuingspreading of infection among the population, and in the meantime maintain aregular daily life, is early detection of infected contagious people. Up tonow, the most reliable method for SARS-CoV-2 detection is reverse-transcriptasePCR test (RT-PCR). It is possible to detect the virus even if there is only oneRNA strand in the sample, and run hundreds of samples simultaneously. Thismethod has a few disadvantages, such as high cost, is time consuming, the needfor medical laboratories and skilled staff to perform the test, and the majorflaw: the lack of appropriate number of available tests. The latterly prominentOmicron variant (B.1.1.529) and its derivatives have caused a tremendousincrease in the number of infected people due to its enhanced transmissibility.This all emphasizes the high demand for easy-to-use, cheap and availabledetection tests.

A Comparison Study of the Detection Limit of Omicron SARS-CoV-2 Nucleocapsid by various Rapid Antigen Tests