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Estimating magnetic susceptibility using MRI depends on inverting a forwardrelationship between the susceptibility and measured Larmor frequency. However,an often-overlooked constraint in susceptibility fitting is that the Larmorfrequency is only measured inside the sample, and after background fieldremoval, susceptibility sources should only reside inside the same sample. Herewe test the impact of accounting for such effects in susceptibility fitting anddemonstrate that such effects should not be ignored.

To mask or not to mask? Investigating the impact of accounting for spatial frequency distributions and susceptibility sources on QSM quality