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Drug delivery through electroporation could be highly beneficial for thetreatment of different types of diseased tissues within the human body. In thiswork, a mathematical model of reversible tissue electroporation is presentedfor injecting drug into the diseased cells. The model emphasizes the tissueboundary where the drug is injected as a point source. Drug loss from thetissue boundaries through extracellular space is studied. Multiple pulses areapplied to deliver a sufficient amount of drug into the targeted cells. The setof differential equations that model the physical circumstances are solvednumerically. This model obtains a mass transfer coefficient in terms of porefraction coefficient and drug permeability. It controls the drug transport fromextracellular to intracellular space. The drug penetration throughout thetissue is captured for the application of different pulses. The boundaryeffects on drug concentration are highlighted in this study. The advocatedmodel is able to perform homogeneous drug transport into the cells so that theaffected tissue is treated completely. This model can be applied to optimizeclinical experiments by avoiding the lengthy and costly in vivo and in vitroexperiments.

A model for reversible electroporation to deliver drugs into diseased tissues