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The formation of amyloid plaques in the cortical and hippocampal brainregions caused by abnormal deposition of extracellular amyloid \b{eta}-protein(A\b{eta}) is a characteristic pathological hallmark of early Alzheimer'sdisease (AD), while label-free graphic rendering of diseased amyloid plaques invivo is still a highly challenging task. Herein, by ingeniously extracting thepolarization-sensitive optical absorption of amyloid plaques via photoacoustic(PA) technique, a novel PA Mueller matrix (PAMM) tomography that capable ofproviding three new conformational parameters of molecules is developed torealize depth-resolved label-free imaging of amyloid plaques. Whole brain PAMMimaging on different stages of APP/PS1 transgenic AD mice has been performed todemonstrate its ability for in situ/in vivo quantitative three-dimensional (3D)detection of amyloid plaques and its great potential for monitoring early ADpathological development without labeling.

Label free visualization of amyloid plaques in Alzheimer's disease with polarization-sensitive photoacoustic Mueller matrix tomography