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Once the magnesium alloy was implanted in the body, it was immediatelycovered with plasma proteins. The coated alloy surface promoted the adsorptionand growth of osteoblasts. Herein, in vitro biological reactions of the ZK60and AZ31 magnesium alloys were analyzed with and without plasma proteinsincubation. The plasma proteins adsorbed on the magnesium alloy werecharacterized using mass spectrometry (MS). The MS results show that proteinsrelated to bone cells such as fibrinogen, vitronectin, fibronectin, andprothrombin are prone to adsorbed on the surface of the alloys than otherproteins. These proteins restrain the degradation of Mg alloys and promote theadsorption and growth of bone cells, which demonstrated by the immersion testsand biocompatibility assays. Furthermore, molecular dynamics simulations wereused to analyze the details of the adsorptions of fibrinogen, fibronectin, andprothrombin on ZK60 and AZ31at atomic level. It is revealed that the type ofresidues adsorbed on the surface of the material has an important effect onprotein adsorption.

MD simulations and experiments of plasma proteins adsorption to the biodegradable magnesium alloys to facilitate cell response