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The origin of life is shrouded in mystery, with few surviving clues, obscuredby evolutionary competition. Previous reviews have touched on the complementaryapproaches of top-down and bottom-up synthetic biology to augment ourunderstanding of living systems. Here we point out the synergies between thesefields, especially between bottom-up synthetic biology and origin of liferesearch. We explore recent progress made in artificial cell compartmentationin line with the crowded cell, its metabolism, as well as cycles of growth anddivision, and how those efforts are starting to be combined. Though thecomplexity of current life is among its most striking characteristics, none oflife's essential features require it, and they are unlikely to have emergedthus complex from the beginning. Rather than recovering the one true originlost in time, current research converges towards reproducing the emergence ofminimal life, by teasing out how complexity and evolution may arise from a setof essential components.

Origin of life from a maker's perspective -- focus on protocellular compartments in bottom-up synthetic biology