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Presented with sensory challenges, living cells employ extensive noisy,fluctuating signalling and communication among themselves to compute aphysiologically proper response which often results in symmetry breaking. Wepropose, based on the results of a coupled stochastics oscillators model thatbiological computation mechanism undertaken by insulin secreting beta-cellsconsists of a combination of dual intracellular Ca$^{2+}$ release processes toensure multilayered exploration contributing to enhanced robustness andsensitivity. The computational output is what is macroscopically observed asdisorder-order phase transition in collective beta-cell response to nutrientconcentration increase. Based on the analogies from previoulsy describedexamples of biological computation, we argue that the initial response may befollowed by an adaptive phase to expand the sensory spectrum and consolidatememory.

Collective biological computation of metabolic economy