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Living cells need a constant availability of certain resources to have asustained gene expression process. Limited availability of cellular resourcesfor gene expression, like ribosomes, along with a variation of resourceaffinity, significantly modifies the system dynamics. Factors like thevariation in rate of binding, or variation in efficiency of the recruitedresource have the potential to affect crucial dynamical phenomena like cellfate determination. In this paper, we have taken a very important motif, abistable genetic toggle switch, and explored the effect of resource imbalancein this circuit in terms of the bifurcations taking place. We show that initialasymmetric biasing to resource via resource affinity or gene copy number,significantly modifies the cell fate transition, both in pitchfork and saddlenode type bifurcation. Our study establishes that in a limited resourceenvironment, controlled resource allocation can be an important factor forrobust functioning of the synthetic or cellular genetic switches.

Resource allocation determines alternate cell fate in Bistable Genetic Switch