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The paper investigates the increase in the natural magnetically controlledproperties of probiotic microorganisms Lactobacillus rhamnosus GG (LGG) andtheir ability to form magnetic sensitive inclusions (MsI). The magneticsusceptibility of LGG was increased by modifying the nutrient mediumcomposition and by cultivating the probiotic culture in a constant magneticfield. Therefore, this study can be useful for their further use asmagnetically controlled vectors, since it is being extensively researched forthe use in targeted drug delivery in cancer treatment, for the prevention ofchemotherapy complications, etc. The results of this study indicate thatgrowing microorganisms with natural magnetically-guided properties in amodified medium with iron chelate and in an external magnetic field leads to anincrease in the magnetic susceptibility of LGG by 1,8 and 2,6 times,respectively, compared with the control. The best magnetic susceptibility wasrecorded for LGG suspensions, which were grown in a constant magnetic field andcultured in modified medium with iron chelate. The LGG suspension, grown bothin a constant magnetic field and on a modified medium with iron chelate, hadthe highest magnetic susceptibility and was 4.8 times larger than the control.

Control of magnetic susceptibility of probiotic strain Lactobacillus Rhamnosus GG