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Cervical cancer threatens the health of women seriously. Radiotherapy is oneof the main therapy methods but with high risk of acute hematologic toxicity.Delineating the bone marrow (BM) for sparing using computer tomography (CT)images to plan before radiotherapy can effectively avoid this risk. Comparingwith magnetic resonance (MR) images, CT lacks the ability to express theactivity of BM. Thus, in current clinical practice, medical practitionersmanually delineate the BM on CT images by corresponding to MR images. However,the time?consuming delineating BM by hand cannot guarantee the accuracy due tothe inconsistency of the CT-MR multimodal images. In this study, we propose amultimodal image oriented automatic registration method for pelvic BM sparing,which consists of three-dimensional bone point cloud reconstruction, a localspherical system iteration closest point registration for marking BM on CTimages. Experiments on patient dataset reveal that our proposed method canenhance the multimodal image registration accuracy and efficiency for medicalpractitioners in sparing BM of cervical cancer radiotherapy. The methodproposed in this contribution might also provide references for similar studiesin other clinical application.

Bone marrow sparing for cervical cancer radiotherapy on multimodality medical images