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Objective: Multi-shot interleaved echo planer imaging can obtaindiffusion-weighted images (DWI) with high spatial resolution and lowdistortion, but suffers from ghost artifacts introduced by phase variationsbetween shots. In this work, we aim at solving the challenging reconstructionsunder inter-shot motions between shots and a low signal-to-noise ratio.Methods: An explicit phase model with paired phase and magnitude priors isproposed to regularize the reconstruction (PAIR). The former prior is derivedfrom the smoothness of the shot phase and enforced with low-rankness in thek-space domain. The latter explores similar edges among multi-b-value andmulti-direction DWI with weighted total variation in the image domain. Results:Extensive simulation and in vivo results show that PAIR can remove ghostartifacts very well under a high number of shots (8 shots) and significantlysuppress the noise under the ultra-high b-value (4000 s/mm2). Conclusion: Theexplicit phase model PAIR with complementary priors has a good performance onchallenging reconstructions under inter-shot motions between shots and a lowsignal-to-noise ratio. Significance: PAIR has great potential in advancedclinical DWI applications and brain function research.

A Paired Phase and Magnitude Reconstruction for Advanced Diffusion-Weighted Imaging