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Precision measurements of heavy-flavor hadroproduction at the Large HadronCollider (LHC) have the ability to probe heavy-flavor parton distributionfunctions (PDFs) in the proton. Sensitivity of inclusive $B^\pm$ mesonproduction cross section measurements at LHCb 13 TeV to the bottom-quark PDF isillustrated by using theory predictions obtained with a the S-ACOT-MPS generalmass variable flavor number (GMVFN) scheme within the QCD factorizationformula. This approach can easily be extended to other heavy-flavor productionprocesses, such as $Z$ boson production in association with a bottom- or acharm-jet. The inclusion of such measurements will represent an importantimprovement for future global QCD analyses that aim at reducing uncertaintiesof heavy-flavor PDFs, provided that a consistent general mass treatment in $pp$collisions is used.  This work is related to the activities of the Snowmass topic groups EF03, andEF06.

Probing heavy-flavor parton distribution functions at hadron colliders