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Purpose: This work proposes a novel RF pulse design for parallel transmit(pTx) systems to obtain uniform saturation of semisolid magnetization forMagnetization Transfer (MT) contrast in the presence of transmit field($B_1^+$) inhomogeneities. The semisolid magnetization is usually modeled asbeing purely longitudinal, with the applied $B_1^+$ field saturating but notrotating its magnetization, thus standard pTx pulse design methods do notapply. Theory and Methods: Pulse design for Saturation Homogeneity (PUSH)optimizes pTx RF pulses by considering uniformity of root-mean squared $B_1^+$,$B_1^{rms}$, which relates to the rate of semisolid saturation. Here weconsidered designs consisting of a small number of spatially non-selectivesub-pulses optimized over either a single 2D plane or 3D. Simulations and invivo experiments on a 7T Terra system with an 8-TX Nova head coil in 5 subjectswere carried out to study the homogenization of $B_1^{rms}$ and of the MTcontrast by acquiring MT ratio maps. Results: Simulations and in vivoexperiments showed up to 6 and 2 times more uniform $B_1^{rms}$ compared tocircular polarized (CP) mode for 2D and 3D optimizations, respectively. Thistranslated into 4 and 1.25 times more uniform MT contrast, consistently for allsubjects, where 2 sub-pulses were enough for the implementation and coil used.Conclusion: The proposed PUSH method obtains more uniform and higher MTcontrast than CP mode within the same SAR budget.

Parallel transmit PUlse design for Saturation Homogeneity (PUSH) for Magnetization Transfer imaging at 7T