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Synthetic genetic circuits are implemented in living cells for theiroperation. During gene expression, proteins are produced from the respectivegenes, by formation of complexes through the process of transcription andtranslation. In transcription the circuit uses RNAP, etc. as resource from thehost cell and in translation, ribosome, tRNA and other cellular resources aresupplied to the operating circuit. As the cell contains these resources inlimited number, the circuit can suffer from unprecedented resource competitionwhich might destroy the circuit functionality, or introduce some emergentresponses. In this paper, we have studied a three-gene motif under resourcecompetition where interesting behaviour, similar to regulatory responses occurdue to limited supply of necessary resources. The system of interest exhibitsprominent changes in behaviour which can be observed experimentally. We focuson two specific aspects, namely, dynamic range and half-induction point, whichinherently describe the circuit functionalities, and can be affected bycorresponding resource affinity and availability.

Emergent Regulatory Response and Shift of Half induction point under Resource Competition in Genetic circuits