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Although matrix metalloproteinases (MMPs) are implicated in the regulation ofnumerous physiological processes, evidences of their pathological roles havealso been obtained in the last decades, making MMPs attractive therapeutictargets for several diseases. Recent discoveries of their involvement incentral nervous system (CNS) disorders, and in particular in Alzheimer'sdisease (AD), have paved the way to consider MMP modulators as promisingtherapeutic strategies. Over the past few decades, diverse approaches have beenundertaken in the design of

Matrix metalloproteinases as new targets in Alzheimer's disease: Opportunities and Challenges