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PURPOSE: To develop an automated algorithm allowing extraction ofquantitative corneal transparency parameters from clinical spectral-domain OCTimages. To establish a representative dataset of normative transparency valuesfrom healthy corneas.  METHODS: SD-OCT images of 83 normal corneas (ages 22-50 years) from astandard clinical device (RTVue-XR Avanti, Optovue Inc.) were processed. Apre-processing procedure is applied first, including a derivative approach anda PCA-based correction mask, to eliminate common central artifacts (i.e.,apex-centered column saturation artifact and posterior stromal artifact) andenable standardized analysis. The mean intensity stromal-depth profile is thenextracted over a 6-mm-wide corneal area and analyzed according to ourpreviously developed method deriving quantitative transparency parametersrelated to the physics of light propagation in tissues, notably tissularheterogeneity (Birge ratio; $B_r$), followed by the photon mean-free path($l_s$) in homogeneous tissues (i.e., $B_r \sim 1$).  RESULTS: After confirming stromal homogeneity ($B_r < 10$, IDR: 1.9-5.1), wemeasured a median $l_s$ of 570 $\mu$m (IDR: 270-2400 $\mu$m). Consideringcorneal thicknesses, this may be translated into a median fraction oftransmitted (coherent) light $T_{coh(stroma)}$ of 51$\%$ (IDR: 22-83$\%$). Nostatistically significant correlation between transparency and age or thicknesswas found.  CONCLUSIONS: Our algorithm provides robust and quantitative measurement ofcorneal transparency from standard clinical SD-OCT images. It yields lowertransparency values than previously reported, which may be attributed to ourmethod being exclusively sensitive to spatially coherent light. Excludingimages with central artifacts wider than 300 $\mu$m also raises our median$T_{coh(stroma)}$ to 70$\%$ (IDR: 34-87$\%$).

Objective assessment of corneal transparency in the clinical setting with standard SD-OCT devices