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Liposomes that achieve a heterogeneous and spatially organized surfacethrough phase separation have been recognized to be a promising platform fordelivery purposes. However, their design and optimization throughexperimentation can be expensive and time-consuming. To assist with the designand reduce the associated cost, we propose a computational platform formodeling membrane coarsening dynamics based on the principles of continuummechanics and thermodynamics. This model couples phase separation to lateralflow and accounts for different membrane fluidity within the different phases,which is known to affect the coarsening dynamics on lipid membranes. Thesimulation results are in agreement with the experimental data in terms ofliquid ordered domains area fraction, total domains perimeter over time andtotal number of domains over time for two different membrane compositions(DOPC:DPPC with a 1:1 molar ratio with 15% Chol and DOPC:DPPC with a 1:2 molarratio with 25% Chol) that yield opposite and nearly inverse phase behavior.This quantitative validation shows that the developed platform can be avaluable tool in complementing experimental practice. Keywords: MulticomponentMembranes; Membrane fluidity; Membrane Phase Separation; ComputationalModeling; Fluorescence Microscopy; Liposomes

Lipid domain coarsening and fluidity in multicomponent lipid vesicles: A continuum based model and its experimental validation