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Current metagenome assemblers developed for short sequence reads or noisylong readswere not optimized for accurate long reads. Here we describehifiasm-meta, a new metagenome assembler that exploits the high accuracy ofrecent data. Evaluated on seven empirical datasets, hifiasm-meta reconstructedtens to hundreds of complete circular bacterial genomes per dataset,consistently outperforming other metagenome assemblers.

Metagenome assembly of high-fidelity long reads with hifiasm-meta