English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Numerous studies of the tumor microenvironment, interspecies xenografting,and limb regeneration suggest the existence of a tissue spatial code [TSC] thatcontrols tissue structure in a quasi "epigenetic" fashion. Epigenetic is aninadequate label, because this information does not act directly upon DNAmolecules like methylation. A broader term is needed to capture the diversityof three-dimensional spatial codes in biology. One such term is HeritableNongenetic Information [HNI], which encompasses the TSC. The term heritable isappropriate because this information is passed onto offspring, otherwise itwould have disappeared during evolution. Another reason for the heritability ofHNI is that the spatial information observed in tissues is not reducible to thelaws of physics, meaning structures like epithelial tubes or neural circuits donot spontaneously form in an aqueous solution. Pre-existing physiologicalinformation in the microenvironment is necessary.

Heritable Nongenetic Information in the Form of the DNA-Autonomous  Tissue Spatial Code that Governs Organismal Development, Tissue Regeneration,  and Tumor Architecture