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Hyperthermia therapy (HT) is used to treat diseases through heating of hightemperature usually in conjunction with some other medical therapeutics likechemotherapy and radiotherapy. In this study, we propose a promisingthermostatic hyperthermia method that uses high-intensity focused ultrasound(HIFU) for clinical tumor treatment combined with diagnostic ultrasound imageguidance and non-invasive temperature monitoring through the speed of sound(SOS) imaging. HIFU heating is realized by a ring ultrasound transducer arraywith 256 elements. The inner structure information of thigh tissue is obtainedby B-mode ultrasound imaging. Since the relationship between the temperatureand the SOS in the different human tissue is available, the temperaturedetection is converted to the SOS detection obtained by the full-wave inversion(FWI) method. Simulation results show that our model can achieve expectedthermostatic hyperthermia on tumor target with 0.2 degree maximum temperaturefluctuation for 5 hours. This study verifies the feasibility of the proposedthermostatic hyperthermia model. Furthermore, the temperature measurement canshare the same ultrasound transducer array for HIFU heating and B-modeultrasound imaging, which provides a guiding significance for clinicalapplication.

Thermostatic Hyperthermia with Non-invasive Temperature Monitoring through Speed of Sound Imaging