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To rapidly obtain high resolution T2, T2* and quantitative susceptibilitymapping (QSM) source separation maps with whole-brain coverage and highgeometric fidelity. We propose Blip Up-Down Acquisition for Spin And GradientEcho imaging (BUDA-SAGE), an efficient echo-planar imaging (EPI) sequence forquantitative mapping. The acquisition includes multiple T2*-, T2'- andT2-weighted contrasts. We alternate the phase-encoding polarities across theinterleaved shots in this multi-shot navigator-free acquisition. A field mapestimated from interim reconstructions was incorporated into the jointmulti-shot EPI reconstruction with a structured low rank constraint toeliminate geometric distortion. A self-supervised MR-Self2Self (MR-S2S) neuralnetwork (NN) was utilized to perform denoising after BUDA reconstruction toboost SNR. Employing Slider encoding allowed us to reach 1 mm isotropicresolution by performing super-resolution reconstruction on BUDA-SAGE volumesacquired with 2 mm slice thickness. Quantitative T2 and T2* maps were obtainedusing Bloch dictionary matching on the reconstructed echoes. QSM was estimatedusing nonlinear dipole inversion (NDI) on the gradient echoes. Starting fromthe estimated R2 and R2* maps, R2' information was derived and used in sourceseparation QSM reconstruction, which provided additional para- and dia-magneticsusceptibility maps. In vivo results demonstrate the ability of BUDA-SAGE toprovide whole-brain, distortion-free, high-resolution multi-contrast images andquantitative T2 and T2* maps, as well as yielding para- and dia-magneticsusceptibility maps. Derived quantitative maps showed comparable values toconventional mapping methods in phantom and in vivo measurements. BUDA-SAGEacquisition with self-supervised denoising and Slider encoding enabled rapid,distortion-free, whole-brain T2, T2* mapping at 1 mm3 isotropic resolution in90 seconds.

BUDA-SAGE with self-supervised denoising enables fast, distortion-free, high-resolution T2, T2*, para- and dia-magnetic susceptibility mapping